In 1820, a very unique man named Martin Fugate immigrated to the United States from France. Martin Fugate, a French orphan, married a woman named Elizabeth around 1820. ABCNews.com was unable to determine if Benjamin Stacy is still alive -- he would be 37 today. Negotiations initiated by France and Algeria led to peace agreements (January 11, 1992 in Mali and 1995 in Niger). The Fugate progeny had a genetic condition called methemoglobinemia, which was passed down through a recessive gene and blossomed through intermarriage. This blocks blue coloring from surfacing in their eyes, resulting in a steely gray hue. They get their nickname from the blue robes they wear. The area code for Cussy is 14214 (also known as code INSEE), and the Cussy zip code is 14400. The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the "Blue People of Kentucky", are notable for having been carriers of a genetic trait that led to the blood disorder methemoglobinemia, which causes the appearance of blue-tinged skin. Stacy is the great-great-great-great-grandson of Martin Fugate and Elizabeth Smith – but by this point, the blue people of Kentucky are just a memory. He married Elizabeth Smith, who also carried the recessive gene. There are many websites that suggest that the RH negative people come from the lost continent of Atlantis, so let’s explore this theory. Doctors Begin to Study The Blue Fugates In the late 1950s, a hematologist named Martin Cawein from the University of Kentucky was fascinated by the stories of the blue Fugate family. Cawein and Pendergrass began to ask questions -- "Do you have any relatives who are blue?" As coal mining arrived in Kentucky in 1912 and the Fugates moved outside of Troublesome Creek, the blue people began to disappear. Even those who looked normal were carriers of the recessive gene that caused the disorder. As the story goes, Martin Fugate, a French orphan, settled on the banks of eastern Kentucky's Troublesome Creek around 1820 to claim a land grant. The predisposition to be born with the genetic disorder kept passing on to each new generation. ", 24/7 coverage of breaking news and live events. Did you ever wonder how much of this stereotype is true? She remembered a dark blue woman who had come to the county health department on a frigid afternoon seeking a blood test. "There was a pain not seen in lab tests," wrote Trost. Since neither parent had symptoms of methemoglobinemia, they were shocked and confused, and no one could offer an explanation. Hemoglobin is responsible for distributing oxygen to the body and without oxygen, the heart, brain and muscles can die. Later in 1965 he was famous for another reason. Normally diaphorase converts methemoglobin back to hemoglobin. The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. Their ancestral line began six generations earlier with a French orphan, Martin Fugate, who settled in Eastern Kentucky. In 1820, a very unique man named Martin Fugate immigrated to the United States from France. In methemoglobinemia, the hemoglobin is unable to carry oxygen and it also makes it difficult for unaffected hemoglobin to release oxygen effectively to body tissues. Once he was in Kentucky, he met and married a red haired woman named Elizabeth Smith. Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin -- a form of hemoglobin -- is produced, according to the National Institutes for Health. By the time reports appeared in the media on the disorder, the Stacy family was upset with insinuations about in-breeding that fed into stereotypes of backwoods Appalachia. In France, people born today can expect to live to 82.4 years compared to an average life expectancy of 80.6 years. Despite being one of the rarer pigments, some countries have high populations of blue-eyed people, particularly in Europe. I do have a thought for you, or thoughts. Martin and Elizabeth Fugate would go on to have seven children together, and four of them were born with blue skin. Even though there is a high number of blond and blue-eyed people living in Britain today, the highest percentage of blue eyes is recorded in South East Scotlandwith 57%. Luna married John E. Stacy and they had 13 children. So one of Martin and Elizabeth’s sons, Zachariah, married Elizabeth’s sister (Yes, you read that correctly. The most detailed account, "Blue People of Troublesome Creek," was published in 1982 by the University of Indiana's Cathy Trost. I just knew that patient was going to die right there in the health department, but she wasn't a'tall alarmed. So they continued to live deep in the woods, for fear of being called a monster. But the Fugates' story still offers a window into a medical mystery that was solved through modern genetics and the sleuth-like energy of Dr. Madison Cawein III, a hematologist at the University of Kentucky's Lexington Medical Clinic. There have been numerous books that say that the people of Atlantis went to live in the Pyrenees Mountains of France and Spain, the northern Africa area of Morocco and Egypt, and to the Americas. That Cussy comes to revere her title as “Book Woman” over her given name (which links her to the ancestral home of the Blue People in the Normandy … But in the summer in France, most people don’t have air conditioning and are sweating all the time, so in that case, I think a daily shower is necessary. The ancestral line began with a French orphan, Martin Fugate, who settled in Eastern Kentucky. Not myth or legend; The Blue People of Kentucky were an isolated enclave of Appalachian people who lived with an embarrassing skin discoloration until a young hematologist took notice and found a solution. This close relation triggered one of the bloodlines with the highest percentages of Methemoglobinemia that was so strong, the blue skin lasted in their family for over 150 years. -- and mapped a family tree and took blood samples. The town of Cussy is located in the department of Calvados of the french region Basse-Normandie.The town of Cussy is located in the township of Bayeux part of the district of Bayeux. Of their seven children, four were reported to be blue. Turn on desktop notifications for breaking stories about interest? Most of the founders were already married, and there were not enough single people going around for every one of their children to have a partner. Because these blue veins were only seen at the nobles and upper-class people of Spain, people started to refer to them as “blue bloods”. That suggested an inbred line that had been passed from generation to generation. Little did they know that their union would create shades o… These people who were born with blue skin were embarrassed, and even though their families accepted them, they knew that the rest of the world would not. The village of Cussy is a small village located north west of France. One of Martin and Elizabeth Fugate's blue boys, Zachariah, married his mother's sister. There were no railroads and few roads outside the region, so the community remained small and isolated. Normally, Methemoglobinemia is so rare, that this condition would no longer show up in the children of the next generation. People lived in log cabins that were closely clustered together, and there would not be a railroad anywhere nearby to bring in new settlers until 1912. The blue people of Troublesome Creek had methemoglobinemia, a metabolic condition affecting hemoglobin, the four-part protein that carries oxygen bound to an iron atom at each subunit’s core. He was born with blue skin, and his family had abandoned him in an orphanage when he was a baby. Isolation and in-breeding passed on the disorder. The most detailed account, "Blue People of Troublesome Creek," was published in 1982 by the University of Indiana's Cathy Trost, who described Benjy's skin as "almost purple.". People with hazel eyes are often mistaken for having green eyes. Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). I don’t think MOST people would stink if they took a shower, say, every other day. It is so incredibly rare, nobody has ever seen an example of it since. She told me that her family was the blue Combses who lived up on Ball Creek. Two conditions cause people to live and be (literally) blue. In order for all the people of the world to see the color blue today, there would have had to have been multiple identical genetic mutations occurring in every part of the globe – pretty much at the same time – be dominant and produce a significant evolutionary benefit. Complications may include seizures and heart arrhythmias.. Methemoglobinemia can be due to certain medications, chemicals, or food or it can be inherited from a person's parents. In an unusual story that involves both genetics and geography, an entire family from isolated Appalachia was tinged blue. One of their sons, Levy, married a Ritchie girl and had eight children, one of them Luna. Some of the pink-skinned family members moved away in the 1900’s, but for those who stayed within their comfort zone of Troublesome Creek, it only forced them to continue picking someone to marry from one of the four families. Mar 14, 2017 - Explore Carol Kline's board "Blue Fugates of Kentucky", followed by 227 people on Pinterest. Martin Fugate came to Troublesome Creek (near Hazard) from France in 1820 and… well… he happened to be blue. Doctors say Benjy likely carried only one gene for methemoglobinemia, because he eventually had normal skin tones, and the likelihood of him marrying a woman with the same recessive gene would have been small. Blond hair percentage: 56 Blue eyes percentage: 48 Since throughout the British history there were many migrations and fluctuations of peoples on its territory, they have all left their trace in the faces of today’s people of Britain. Even though they were from different countries, and the odds were probably a billion-to-one, they both carried the recessive gene for an extremely rare condition known as Methemoglobinemia. She looked like she was having a heart attack. Protestors block an access to the A11 and A 28 highways near Le Mans, northwestern France, on November 18, 2018 a day after tens of thousands of people blocked roads across France … Feb. 22, 2012 -- Benjamin "Benjy" Stacy so frightened maternity doctors with the color of his skin -- "as Blue as Lake Louise" -- that he was rushed just hours after his birth in 1975 to University of Kentucky Medical Center. The carcinogen benzene and nitrites used as meat additives can also be culprits, as well as certain antibiotics, including dapsone and chloroquine. See more ideas about kentucky, people, medical oddities. "Her face and her fingernails were almost indigo blue," she told Trost. He married a Kentuckian named Elizabeth Smith, who also carried the blue gene, so to speak. It was real bad in her.” Benjy Stacy was the latest child born in a long line of Fugates – the blue people of Kentucky – who had lived in the Appalachian mountains of Kentucky for the past 197 years. At the same time, DNA testing of remains of ancient Irish people suggests that some of the earliest human arrivals on the island originally came from mu… They lived to be in their 80s and 90s, without ever suffering from heart or liver disease. Unbeknownst to the couple, they were coincidentally both carriers of a recessive gene (met-H) that caused methemoglobinemia, which can tint the skin of sufferers blue. There were no railroads and few roads outside the region, so the community remained small and isolated. In February 2019, 2,762 people had painted themselves blue and gathered at a regional carnival in Lauchringen, Germany, taking home the world title for “Most people dressed as Smurfs.” The genetic form of methemoglobinemia is caused by one of several genetic defects, according to Tefferi. Most of what scientists know about the family was discovered by Cawein, the grandson of Kentucky's poet laureate, who had done pioneering research on L-dopa as a treatment for Parkinson's disease. The bluest of the bunch was Luna, and she lived a healthy life, bearing 13 children before she died at the age of 84. The blue people are a common story to the Appalachians. Medical breakthrough saves girls with rare debilitating disease. All of the blue Fugates he tested had the enzyme deficiency, just like the Alaskans Scott had observed. 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